- This is Director Timur Bekmambetov's first American film.
- Originally a comic book by Top Cow Productions written by Mark Millar.
- In the office at the end of the film a nameplate is visible on one of the cubicle walls. The nameplate reads "J.G Millar" which is a composite of writer Mark Millar and artist J.G. Jones, on whose comic the film is based.
- Screenwriters Michael Brandt and Derek Haas named several of the movie's characters after people from their college alma mater, Baylor University. Robert Darden, the name of Wesley's first target for assassination, is the writing professor in whose class they first met. (They have used the name Darden for the first victim in several other films, as well: 3:10 to Yuma (2007) and 2 Fast 2 Furious (2003)). Sloan, the character played by Morgan Freeman, is taken from the university's previous president, who was forced to step down under pressure from faculty and alumni.
- One of Cross' victims is identified by the Gunsmith as "Rictus". The main antagonist in the comic book is Mister Rictus.
- In the Russian edit of the movie, most of the texts visible on screen are translated via CGI: the texts on the ATM, the shop register, the flying keyboard letters (which spell the Russian curse "PSHEL NAH" instead of "FUCK YOU").
- For the Russian dubbing, many Russian film stars from Nochnoy dozor (2004), Dnevnoy dozor (2006) and Ironiya sudby. Prodolzhenie (2007) took part: Sergey Bezrukov for James McAvoy, Galina Tyunina for Angelina Jolie, Yuri Kutsenko, Valeri Zolotukhin and others. The Russian dubbing script was written by Sergei Lukyanenko.
- After Wesley leaves his job, you can see a sign for "Wicked: The Musical" in the background. Producer Marc E. Platt produced the Broadway show.
- The man pictured in the poster next to Cross' shoulder when he is on the train is the president of the Czech Republic, Václav Klaus.
- Angelina Jolie says she based her role in Wanted on Clint Eastwood.
>>> WARNING: Here Be Spoilers <<<
Trivia items below here contain information that may give away important plot points. You may not want to read any further if you've not already seen this title.
- SPOILER: In the final library scene, Fox decides to follow the code, and the bullet she shoots has the word 'Goodbye' engraved on it. You can see the word clearly just prior to it entering the first assassin's head.
- SPOILER: At the end of the movie, where we see Wesley at his cubicle alone, the nameplate next to his says "J.G. Millar". This is a combination of the "Wanted" comic's artist J.G. Jones and author Mark Millar.
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